Drugs / Botulinum toxin
last change Aug 2026 re-read 2 minutes ago

Botulinum toxin

Protein / enzyme biologic

Developed for
eyelid disorder · stroke disorder · atrial fibrillation · cervical dystonia · compartment syndrome · movement disorder · spastic hemiplegia · traumatic brain injury
+46 more · anismus · arthropathy, erosive · benign essential blepharospasm · bruxism · carpal displacement · cerebral palsy · cerebral palsy spastic hemiplegic · chronic pain syndrome · clubfoot · congenital contractures · disease of orbital part of eye adnexa · dystonic disorder · esophageal disorder · excessive tearing · eye adnexa disorder · eyelid degenerative disorder · facial paralysis · gingival overgrowth · hemiplegia · interstitial cystitis · keloid formation · masticatory muscles, hypertrophy of · osteoarthritis, knee · overactive bladder · Parkinson disease · pelvis syndrome · reactive cutaneous fibrous lesion · rotator cuff syndrome · scleroderma · seborrheic dermatitis · spastic diplegia · strabismus · ventricular tachycardia · vulvar disease · vulvodynia · cardiac rhythm disease · carpal tunnel syndrome · constipation disorder · diabetes mellitus · essential tremor · paroxysmal atrial fibrillation · peripheral neuropathy · persistent atrial fibrillation · Raynaud disease · rectal disorder · ulcer of lower limbs
Investigated by
Galderma R&D · Allergan · Meshalkin Research Institute of Pathology of Circulation · Assistance Publique Hopitaux De Marseille · Hospices Civils de Lyon · University of Miami
+46 more · 375th Medical Group, Scott Air Force Base · Albany Medical College · American Urogynecologic Society · Asir John Samuel · Azienda Ospedaliera Universitaria Integrata Verona · Baylor College of Medicine · Cairo University · Canisius-Wilhelmina Hospital · Centre Hospitalier Universitaire de Nice · Chang Gung Memorial Hospital · Donders Centre for Cognitive Neuroimaging · Fondazione Don Carlo Gnocchi ETS · Fondo Nacional de Desarrollo Científico y Tecnológico, Chile · Foundation University Islamabad · Fox, Donald Munro, M.D., P.C. · HCA International Limited · Hadassah Medical Organization · Henry Ford Health System · HillMed Inc. · Icahn School of Medicine at Mount Sinai · Instituto Nacional de Rehabilitación Pedro Aguirre Cerda · Karen Noblett · King Abdulaziz Medical City · Mackay Medical College · Mayo Clinic · NYU Langone Health · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Taiwan University Hospital · Promobilia Foundation · Rabin Medical Center · Radboud University Medical Center · Ramsay Santé · Rhode Island Hospital · Rigshospitalet, Denmark · St Joseph University, Beirut, Lebanon · Uniformed Services University of the Health Sciences · Universidad de los Andes, Chile · University Hospital, Grenoble · University Hospital, Rouen · University of Houston · University of Ioannina · University of Texas Southwestern Medical Center · Vastra Gotaland Region · Versailles Hospital · Walter Reed National Military Medical Center · Zonguldak Bulent Ecevit University

Trials 53 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT05062902 Sep 2025 → Aug 2027 expected chronic pain syndrome, interstitial cystitis, pelvis syndrome HillMed Inc. Not yet recruiting No outcome recorded
Phase 0 NCT04523506 May 2020 → Apr 2021 scleroderma University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 18 trials
Phase 1 NCT06796985 Feb 2025 → Mar 2027 expected University of Miami Recruiting No outcome recorded
Phase 1 NCT04630873 Nov 2020 → Aug 2025 overdue spastic hemiplegia University of Ioannina Recruiting No outcome recorded
Phase 1 NCT04030767 Sep 2019 → Sep 2020 gingival overgrowth Cairo University Unknown No outcome recorded
Phase 1 NCT02139319 Mar → Jul 2014 osteoarthritis, knee Galderma R&D Completed No outcome recorded
Phase 1 NCT02003027 Jun 2013 → Dec 2015 Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 1 NCT02003001 Jun 2013 → Mar 2016 ventricular tachycardia Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 1 NCT01682733 Aug 2012 → Dec 2014 obesity disorder Mayo Clinic Completed No outcome recorded
Phase 1 NCT00767546 May 2009 → Aug 2010 Parkinson disease, seborrheic dermatitis Rabin Medical Center Unknown No outcome recorded
Phase 27 trials
Phase 2 NCT05012566 Jul 2021 → Jul 2023 facial paralysis Azienda Ospedaliera Universitaria Integrata Verona Unknown No outcome recorded
Phase 2 NCT04409600 Nov 2020 → Dec 2024 compartment syndrome Walter Reed National Military Medical Center Completed No outcome recorded
Phase 2 NCT02982434 Sep 2016 → Dec 2017 atrial fibrillation, ischemic disease Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 2 NCT02623829 Dec 2015 → Mar 2019 keloid formation Icahn School of Medicine at Mount Sinai Completed No outcome recorded
Phase 2 NCT02867787 Mar 2014 → Sep 2016 rotator cuff syndrome Versailles Hospital Unknown No outcome recorded
Phase 2 NCT01955174 Aug 2013 → May 2017 esophageal disorder Hospices Civils de Lyon Completed No outcome recorded
Phase 2 NCT00973999 Sep 2009 → Sep 2011 traumatic brain injury HCA International Limited Withdrawn No outcome recorded
Phase 2/35 trials
Phase 2/3 NCT05478551 Jun 2022 → Dec 2026 expected reactive cutaneous fibrous lesion Henry Ford Health System Active not recruiting No outcome recorded
Phase 2/3 NCT03339921 Dec 2018 → May 2020 compartment syndrome 375th Medical Group, Scott Air Force Base Terminated No outcome recorded
Phase 2/3 NCT02617069 Sep 2015 → Mar 2016 atrial fibrillation Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 2/3 NCT01780636 Jan 2013 → Jan 2014 anismus Karen Noblett Terminated No outcome recorded
Phase 2/3 NCT00133861 Apr 2005 → Jun 2008 cerebral palsy Hospices Civils de Lyon Completed No outcome recorded
Phase 312 trials
Phase 3 NCT05998187 Apr 2025 → Jun 2027 expected University Hospital, Rouen Recruiting No outcome recorded
Phase 3 NCT05008731 Jul 2024 → Feb 2026 congenital contractures Ramsay Santé Terminated No outcome recorded
Phase 3 NCT05990881 Aug 2023 → Dec 2025 overdue carpal displacement, salivary substance, Clostridium botulinum type, thumb deformity Rhode Island Hospital Recruiting No outcome recorded
Phase 3 NCT05148000 Jan → Mar 2023 eyelid disorder Galderma R&D Completed No outcome recorded
Phase 3 NCT05463965 Jul 2022 → Jan 2023 Galderma R&D Completed No outcome recorded
Phase 3 NCT04249583 Feb → Aug 2020 Galderma R&D Completed No outcome recorded
Phase 3 NCT04247074 Feb → Oct 2020 disease of orbital part of eye adnexa Galderma R&D Completed No outcome recorded
Phase 3 NCT04249687 Feb → Sep 2020 eyelid disorder Galderma R&D Completed No outcome recorded
Phase 3 NCT04225260 Jan 2020 → Apr 2021 eyelid disorder Galderma R&D Completed No outcome recorded
Phase 3 NCT04579419 Nov 2019 → Aug 2020 King Abdulaziz Medical City Completed No outcome recorded
Phase 47 trials
Phase 4 NCT06411028 Jan 2025 → May 2027 expected dystonic disorder Radboud University Medical Center Recruiting No outcome recorded
Phase 4 NCT06734598 Dec 2024 → Nov 2025 overdue head and neck cancer National Taiwan University Hospital Recruiting No outcome recorded
Phase 4 NCT06080438 Nov 2022 → Jul 2024 excessive tearing, eyelid disorder University of Miami Terminated No outcome recorded
Phase 4 NCT04829565 Sep 2021 → May 2025 overdue arthropathy, erosive Centre Hospitalier Universitaire de Nice Active not recruiting No outcome recorded
Phase 4 NCT03701919 Jan 2019 → Nov 2022 Albany Medical College Completed No outcome recorded
Phase 4 NCT02786550 Jun 2016 → Jun 2018 eyelid degenerative disorder Chang Gung Memorial Hospital Unknown No outcome recorded
Phase 4 NCT00119886 Apr 2005 → Jun 2008 vulvar disease, vulvodynia Rigshospitalet, Denmark Unknown No outcome recorded
Phase not applicable12 trials
NCT07180394 Sep 2025 → Aug 2030 expected strabismus Foundation University Islamabad Not yet recruiting No outcome recorded
NCT07025642 Jul 2025 → May 2026 overdue overactive bladder Mackay Medical College Recruiting No outcome recorded
NCT06733025 Jan 2025 → Jan 2029 expected spinal cord injury, stroke disorder, traumatic brain injury Vastra Gotaland Region Recruiting No outcome recorded
NCT06593821 Apr 2023 → Jan 2024 bruxism, masticatory muscles, hypertrophy of Zonguldak Bulent Ecevit University Completed No outcome recorded
NCT07124806 Jul → Nov 2022 movement disorder, spastic hemiplegia, stroke disorder Universidad de los Andes, Chile Completed No outcome recorded
NCT04177186 Oct 2020 → Aug 2021 cerebral palsy spastic hemiplegic, spastic diplegia Asir John Samuel Unknown No outcome recorded
NCT03938363 Oct 2019 → Jun 2022 benign essential blepharospasm, cervical dystonia University Hospital, Grenoble Completed No outcome recorded
NCT03836638 May 2019 → Dec 2020 salivary substance, Clostridium botulinum type St Joseph University, Beirut, Lebanon Unknown No outcome recorded
NCT03247868 Mar 2016 → Mar 2018 cervical dystonia Fondazione Don Carlo Gnocchi ETS Unknown No outcome recorded
NCT02244671 Jan 2014 → Jan 2018 eye adnexa disorder Fox, Donald Munro, M.D., P.C. Completed No outcome recorded
Also used as a comparator or background therapy in 21 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04439825 Comparator Jul → Sep 2020 DeNova Research Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02015039 Background Dec 2013 → Sep 2016 focal, segmental or multifocal dystonia National Institute of Neurological Disorders and Stroke (NINDS) Completed No outcome recorded
Phase 26 trials
Phase 2 NCT02008448 Comparator Jun 2013 → Dec 2015 persistent atrial fibrillation Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 2 NCT02008461 Comparator Jun 2013 → Dec 2015 cardiac rhythm disease Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 2 NCT02002923 Comparator Jun 2013 → Jun 2015 paroxysmal atrial fibrillation, persistent atrial fibrillation Meshalkin Research Institute of Pathology of Circulation Unknown No outcome recorded
Phase 2 NCT01842529 Comparator Sep 2012 → Dec 2013 paroxysmal atrial fibrillation Meshalkin Research Institute of Pathology of Circulation Completed No outcome recorded
Phase 2 NCT00701233 Comparator Jun 2012 → Oct 2018 carpal tunnel syndrome University of Minnesota Withdrawn No outcome recorded
Phase 32 trials
Phase 3 NCT05146999 Comparator May → Oct 2022 Galderma R&D Completed No outcome recorded
Phase 3 NCT01586819 Comparator Sep 2011 → May 2013 Loyola University Completed No outcome recorded
Phase 45 trials
Phase 4 NCT05125029 Comparator Feb 2022 → Dec 2025 overdue Raynaud disease Emory University Recruiting No outcome recorded
Phase 4 NCT03302741 Background Nov 2017 → Nov 2019 The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 4 NCT02361749 Comparator Sep 2014 → Aug 2018 constipation disorder Cairo University Unknown No outcome recorded
Phase 4 NCT02472210 Comparator Jul 2014 → Jul 2015 Parkinson disease University Health Network, Toronto Unknown No outcome recorded
Phase 4 NCT01032954 Comparator Nov 2009 → Dec 2010 Hexsel Dermatology Clinic Completed No outcome recorded
Phase not applicable6 trials
NCT07057050 Background Jun → Oct 2025 stroke disorder Cairo University Completed No outcome recorded
NCT06583551 Comparator Jan → Mar 2021 bruxism University of Health Sciences Completed No outcome recorded
NCT03546959 Background Jun 2018 → Feb 2019 stroke disorder Marmara University Completed No outcome recorded
NCT02711995 Comparator Dec 2015 → Sep 2016 essential tremor Weill Medical College of Cornell University Completed No outcome recorded
NCT00845897 Comparator Mar 2005 → Mar 2010 diabetes mellitus, peripheral neuropathy, ulcer of lower limbs Washington University School of Medicine Completed No outcome recorded

Press releases naming this drug 43 releases

DateIssuerRelease
2026-08-04 AbbVie Allergan Aesthetics Announces U.S. FDA Acceptance of Supplemental Biologics License Application for BOTOX® Cosmetic for Masseter Muscle Prominence abbvie.com
2026-07-09 Ipsen Dysport® is the first botulinum toxin to achieve positive topline Phase III results in both episodic and chronic migraine. ipsen.com
2026-06-24 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Introduces The Confidence Collective's Entrepreneur Class of 2026 abbvie.com
2026-05-19 Ipsen Ipsen announces late-breaking data from first head-to-head study comparing Dysport® and Botox® in adults with upper limb spasticity ipsen.com
2026-04-08 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Empowers Women Entrepreneurs Through "The Confidence Collective" for Fourth Year abbvie.com
2025-10-29 AbbVie The One & Only BOTOX® Cosmetic (onabotulinumtoxinA) Day Returns November 19 with the Biggest Celebration of the Year abbvie.com
2025-10-06 AbbVie AbbVie Announces Positive Topline Results from Phase 2 ELATE Trial Evaluating OnabotulinumtoxinA (BOTOX®) for the Treatment of Upper Limb Essential Tremor abbvie.com
2025-09-09 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Unveils "The One & Only" Campaign Featuring Real People and Their Distinctive Stories abbvie.com
2024-11-07 AbbVie Allergan Aesthetics Celebrates Annual BOTOX® Cosmetic (onabotulinumtoxinA) Day abbvie.com
2024-10-18 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Receives FDA Approval for Moderate to Severe Vertical Bands Connecting the Jaw and Neck (Platysma Bands) abbvie.com
2024-09-24 AbbVie Empowering Women Entrepreneurs: 2024 BOTOX® (onabotulinumtoxinA) Cosmetic Grant Recipients Kick Off Crowdfunding Campaigns abbvie.com
2024-09-11 AbbVie Allergan Aesthetics Launches BOTOX® Cosmetic (onabotulinumtoxinA) for Masseter Muscle Prominence (MMP) in Adults in China abbvie.com

Evidence & citations 20 cited values

Every value below carries the sentence it was read from. 78 sources stand behind the page.

FieldValueCited text
Known as Botulinum toxin “The aim of this prospective non-randomized study was to assess the efficacy and safety of endomyocardial botulinum toxin injection in left ventricle for preventing episodes of VT Storm.” NCT02003027
62

“While Botulinum toxin(BoNT) injections are widely used for focal spasticity, surgical interventions remain underutilized despite promising long-term outcomes.” NCT06733025

“Injection of the botulinum toxin is performed in main anatomical zones of ganglionated plexuses of left atrium using Myostar catheter (Biosense Webster).” NCT02008448

“This project aims to explore the therapeutic effect of Botulinum toxin (Botox) injection to the masticatory muscles in the above-mentioned patients.” NCT06734598

“Local injection of Botulinum toxin (BTx) has become a mainstay of the treatment of focal spasticity, particularly in post-stroke patients.” NCT01829763

“The investigators assume that intramuscular injection of botulinum toxin is effective in the treatment of tendinopathy rotator cuff.” NCT02867787

Botulinum toxin produces partial chemical denervation of the muscle resulting in localized reduction in muscle activity” NCT04030767

Botulinum toxin treatment results in a pharmacologic recession of the injected extraocular muscle” NCT07180394

“Focal injections of botulinum toxin (BoNT) are the current best therapy.” NCT02015039

Botulinum Toxin diluted in Sodium Bicarbonate” NCT04579419

Botulinum toxinNCT01631604

NCT05478551

NCT06593821

NCT02008461

NCT00973999

NCT04177186

NCT07025642

NCT02139319

NCT03701919

NCT00927849

NCT00015457

NCT04409600

NCT02244671

NCT01842529

NCT04249687

NCT07124806

NCT02617069

NCT03405948

NCT04829565

NCT02982434

NCT00767546

NCT06583551

NCT06411028

NCT01780636

NCT06080438

NCT02786550

NCT04523506

NCT00119886

NCT00701233

NCT00845897

NCT03836638

NCT02361749

NCT01955174

NCT03938363

NCT01032954

NCT02003001

NCT03546959

NCT02472210

NCT05990881

NCT05998187

NCT01682733

NCT07057050

NCT03339921

NCT05008731

NCT02002923

NCT03247868

NCT02623829

NCT05125029

NCT04630873

NCT02711995

NCT01586819

NCT00133861

NCT01422161

Known as BoNT “The purpose of this study is to evaluate if it is possible to use intravaginal high-density surface electromyography to guide Botulinum neurotoxin (BoNT) injection to treat...” NCT05062902
3

“While Botulinum toxin(BoNT) injections are widely used for focal spasticity, surgical interventions remain underutilized despite promising long-term outcomes.” NCT06733025

“Focal injections of botulinum toxin (BoNT) are the current best therapy.” NCT02015039

“Botulinum neurotoxin (BoNT) is the first-line treatment of ICD” PMID 31478151 Sep 2019

Known as BoNTA “intradetrusor injection of botulinum neurotoxin type A (BoNTA)” NCT07025642
Known as Botox “This project aims to explore the therapeutic effect of Botulinum toxin (Botox) injection to the masticatory muscles in the above-mentioned patients.” NCT06734598
6

“Botulinum toxin (BTX, brand name Botox®), produced naturally by the bacterium Clostridium botulinum and adapted for medical use” NCT03701919

“Urodynamic evaluation before and after Botulinum toxin (Botox) injection.” NCT07025642

“A single session of Botox (Botulinum toxin A) injection was performed.” NCT06583551

“one hundred units of type A botulinum toxin (Botox®, Allergan)” NCT01955174

“Botulinum Toxin commonly known as BOTOX®” NCT01422161

“Biological: Botulinum toxin(Botox)” NCT04523506

Known as Botulin toxin “patients with spastic hemiparesis which will be treated with Botulin toxin at different dilutions.” NCT04630873
Known as Botulinum neurotoxin Botulinum neurotoxin (BoNT) is the first-line treatment of ICD” PMID 31478151 Sep 2019
4

NCT05062902

NCT06796985

NCT03302741

NCT04439825

Known as botulinum neurotoxin type A “intradetrusor injection of botulinum neurotoxin type A (BoNTA)” NCT07025642
Known as Botulinum toxin A “A single session of Botox (Botulinum toxin A) injection was performed.” NCT06583551
1

Botulinum toxin A injection” NCT00701233

Known as Botulinum Toxin Type A Botulinum Toxin Type A for Pain in Advanced Parkinson's Disease” NCT02472210
Known as BTx “Local injection of Botulinum toxin (BTx) has become a mainstay of the treatment of focal spasticity, particularly in post-stroke patients.” NCT01829763
3

“Botulinum toxin (BTX, brand name Botox®), produced naturally by the bacterium Clostridium botulinum and adapted for medical use” NCT03701919

“Improvement of cervical/eyelid control following botulinum toxin (BTX) injections would translate into gait changes.” PMID 38386480 Dec 2023

“Botulinum neurotoxin (BTX)” NCT03302741

Known as BTX A “The study aimed to assess and compare the effectiveness of 4 different methods in the management bruxism: Botulinum toxin (BTX-A), dry needling (DN), pharmacological therapy...” NCT06583551
2

“OBJECTIVE: To determine the effects of botulinum neurotoxin type A (BTX-A) dilution and endplate-targeting in spastic elbow flexors.” PMID 19154823 Jan 2009

“botulinum toxin injection (BTX A)” NCT06411028

Known as Dysport “A volume of 0.5 ml of dissolved toxin, i.e., 100 u Dysport, is injected in each patient” NCT00927849
1

“Botulinum Toxin type-A (Dysport, Ipsen Ltd, Slough, Berkshire)” NCT00973999

Known as incobotulinumtoxin A “All patients underwent conventional CABG. After the main stage of the surgery botulinum toxin (Xeomin, incobotulinumtoxin A, Merz Pharma GmbH \& Co KGaA, Germany; 50 U/1 mL at...” NCT01842529
Known as Intramuscular injection of Botulinum toxin A. (BoNT-A) Intramuscular injection of Botulinum toxin A. (BoNT-A)NCT06583551
Known as QM1114-DP “The investigational product (QM1114-DP) is a BoNT Type A.” NCT04225260
5

QM1114-DP, a Botulinum Toxin Type A (BoNT-A)” NCT04247074

QM1114-DP, a Botulinum Toxin Type A (BoNT-A)” NCT04249583

NCT05463965

NCT05148000

NCT05146999

Known as Vistabex ClinicalTrials.gov intervention name — accepted as the source's own label NCT05012566
Known as Xeomin “Patients with history of paroxysmal atrial fibrillation and indication for coronary artery bypass graft surgery were randomized to botulinum toxin (Xeomin, Merz, Germany; 50...” PMID 26486855 Oct 2015
Action Inhibit “botulinium toxin, which inhibitis acetyl choline realese” NCT00767546
Modality Protein / enzyme biologic “Biological: botulinum toxin injection” NCT01842529
Route Other “after local injection with Botox” NCT00119886