Drugs / Danuglipron
last change Jun 2025 re-read 2 minutes ago

Danuglipron

also known as PF-06882961

Small molecule targets GLP1R via activation

Developed for
obesity disorder · type 2 diabetes mellitus
Investigated by
Pfizer

Trials 20 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 117 trials
Phase 1 NCT06910839 Mar → May 2025 obesity disorder Pfizer Terminated No outcome recorded
Phase 1 NCT06541678 Dec 2024 → Mar 2025 Pfizer Completed No outcome recorded
Phase 1 NCT06567327 Aug 2024 → Mar 2025 obesity disorder Pfizer Completed No outcome recorded
Phase 1 NCT06568731 Aug → Dec 2024 obesity disorder Pfizer Completed No outcome recorded
Phase 1 NCT06153758 Nov 2023 → Sep 2024 Pfizer Completed No outcome recorded
Phase 1 NCT05093205 Oct 2021 → Jul 2022 Pfizer Completed No outcome recorded
Phase 1 NCT04889157 Jul 2021 → Feb 2022 type 2 diabetes mellitus Pfizer Completed No outcome recorded
Phase 1 NCT04839393 Apr → Oct 2021 Pfizer Completed No outcome recorded
Phase 1 NCT04616027 Jan 2021 → Feb 2022 impaired renal function disease, type 2 diabetes mellitus Pfizer Completed No outcome recorded
Phase 1 NCT04604496 Dec 2020 → Jan 2022 Pfizer Completed No outcome recorded
Phase 23 trials
Phase 2 NCT04707313 Jan 2021 → Sep 2023 obesity disorder Pfizer Completed No outcome recorded
Phase 2 NCT04617275 Jan → Nov 2021 obesity disorder, type 2 diabetes mellitus Pfizer Completed No outcome recorded
Phase 2 NCT03985293 Oct 2019 → Jun 2021 type 2 diabetes mellitus Pfizer Completed No outcome recorded

Press releases naming this drug 3 releases

DateIssuerRelease
2025-04-14 Pfizer Pfizer Provides Update on Oral GLP-1 Receptor Agonist Danuglipron pfizer.com
2024-07-11 Pfizer Pfizer Advances Development of Once-Daily Formulation of Oral GLP-1 Receptor Agonist Danuglipron pfizer.com
2023-12-01 Pfizer Pfizer Announces Topline Phase 2b Results of Oral GLP-1R Agonist, Danuglipron, in Adults with Obesity pfizer.com

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 21 sources stand behind the page.

FieldValueCited text
Known as Danuglipron “This randomized, double-blind, placebo-controlled Phase 2b study aimed to assess the efficacy, safety, and tolerability of danuglipron (PF-06882961), an oral small-molecule...” PMID 40539310 Jun 2025
7

“We developed danuglipron (PF-06882961), an oral small-molecule GLP-1R agonist and found it had comparable efficacy to injectable peptidic GLP-1R agonists in a humanized mouse model.” PMID 34127852 Jun 2021

Danuglipron (PF-06882961) is an oral, small-molecule glucagon-like peptide-1 receptor agonist in development for the treatment of type 2 diabetes (T2D) and obesity.” PMID 37840155 Nov 2023

“subjects received PF-06882961 (Danuglipron) 100 mg immediate release tablet as formulation A” NCT04616339

NCT06153758

NCT06568731

NCT06567327

NCT06541678

Known as PF-06882961 “This randomized, double-blind, placebo-controlled Phase 2b study aimed to assess the efficacy, safety, and tolerability of danuglipron (PF-06882961), an oral small-molecule...” PMID 40539310 Jun 2025
15

“We developed danuglipron (PF-06882961), an oral small-molecule GLP-1R agonist and found it had comparable efficacy to injectable peptidic GLP-1R agonists in a humanized mouse model.” PMID 34127852 Jun 2021

“Danuglipron (PF-06882961) is an oral, small-molecule glucagon-like peptide-1 receptor agonist in development for the treatment of type 2 diabetes (T2D) and obesity.” PMID 37840155 Nov 2023

NCT03492697

NCT04617275

NCT03309241

NCT04839393

NCT04616339

NCT04604496

NCT04621227

NCT04889157

NCT06910839

NCT04495140

NCT05093205

NCT03985293

NCT04552470

Action Activate “Glucagon-like peptide 1 receptor agonist” CHEMBL4518483
1

“GLP-1R agonist” PMID 34127852 Jun 2021

Modality Small molecule “an oral small-molecule GLP-1R agonist” PMID 34127852 Jun 2021
Route Oral “single oral doses of PF-06882961” NCT03309241
Target GLP1R “Glucagon-like peptide 1 receptor agonist” CHEMBL4518483