drugset / Trial / NCT00262210
A Comparative Study for Non-Hodgkin's Lymphoma in Hepatitis B Virus Carriers
RandomizedParallel-groupOpen-labelTreatment
Summary
\* AIMS OF THE STUDY 1. To test if steroid-free chemotherapeutic regimens decrease the risk of HBV reactivation and hepatitis development in HBsAg (+) carriers. 2. To compare the efficacy of steroid-free chemotherapeutic regimens with that of steroid-containing regimens in terms of lymphoma control. 3. To study the change of activity of HBV and other hepatotropic viruses during the course of chemotherapy.
Timeline
- Start
- 1995-06
- Primary completion
- —
- Completion
- 1999-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclophosphamide | Other / unclassified | 187.5 mg/m2 | Intravenous |
| Subject | Cyclophosphamide | Other / unclassified | 650 mg/m2 | Intravenous |
| Subject | Epirubicin | Small molecule | 20 mg/m2 | Intravenous |
| Subject | Epirubicin | Small molecule | 60 mg/m2 | Intravenous |
| Subject | Etoposide | Small molecule | 55 mg/m2 | Intravenous |
| Subject | Etoposide | Small molecule | 60 mg/m2 | Intravenous |
| Subject | Prednisolone | Other / unclassified | 60 mg/m2 | Oral |