drugset / Trial / NCT00720577
Study to Evaluate the Effect of Simvastatin, Losartan and Pioglitazone on Patients With Peripheral Arterial Disease.
Phase 0
Completed
164 enrolled
Medtronic Endovascular
FoxHollow Technologies · collabMerck Sharp & Dohme LLC · collab
RandomizedParallel-groupQuadruple-blindBasic science
Summary
Part A. The purpose of this study is to assess the effects of 6 weeks of treatment with, simvastatin, losartan or pioglitazone compared to placebo on the RNA expression profile of lower extremity peripheral arterial atherosclerotic plaque. Part B. The effect of simvastatin, losartan or pioglitazone compared to placebo on protein and lipid biomarkers in lower extremity peripheral arterial atherosclerotic plaque.
Timeline
- Start
- 2005-12
- Primary completion
- 2007-07
- Completion
- 2007-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Losartan | Other / unclassified | 50 mg | — |
| Comparator | Pioglitazone | Small molecule | 30 mg | — |
| Comparator | Simvastatin | Small molecule | 40 mg | — |