Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy

Phase 4 Completed 115 enrolled Duke University Merck Sharp & Dohme LLC · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

We hypothesize that the combination of aprepitant with dexamethasone will provide significantly improved prophylaxis against Postoperative nausea and vomiting compared with the combination of ondansetron and dexamethasone, in patients undergoing craniotomy under general anesthesia.

Timeline

Start: 2007-09
Primary completion: 2009-06
Completion: 2009-06

Publications

Results Habib AS, Keifer JC, Borel CO, White WD, Gan TJ. A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy. Anesth Analg. 2011 Apr;112(4):813-8. doi: 10.1213/ANE.0b013e3181ff47e2. Epub 2010 Nov 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aprepitant	Other / unclassified	40 mg	Oral
Comparator	Ondansetron	Other / unclassified	4 mg	Intravenous
Comparator	Dexamethasone	Small molecule	10 mg	—

Indications

No indication recorded.