High-dose Chemotherapy and Stem Cell Transplantation for Central Nervous System (CNS) Relapse of Aggressive Lymphomas

Phase 2 Unknown 30 enrolled Charite University, Berlin, Germany

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Central nervous system (CNS) relapses of aggressive lymphomas are a rare but devastating complication. There is no therapy standard, conventional approaches are palliative. This study investigates an intensive chemotherapy with CNS penetrating drugs followed by high-dose chemotherapy and autologous stem cell transplantation as a potentially curative approach.

Timeline

Start: 2007-10
Primary completion: 2011-10
Completion: 2012-10

Publications

Korfel A, Elter T, Thiel E, Hanel M, Mohle R, Schroers R, Reiser M, Dreyling M, Eucker J, Scholz C, Metzner B, Roth A, Birkmann J, Schlegel U, Martus P, Illerhaus G, Fischer L. Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas. Haematologica. 2013 Mar;98(3):364-70. doi: 10.3324/haematol.2012.077917. Epub 2012 Dec 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cytarabine	Small molecule	50 mg	Intravenous
Subject	Cytarabine	Small molecule	3000 mg/m2	Intravenous
Subject	Etoposide	Small molecule	150 mg/m2	Intravenous
Subject	Ifosfamide	Small molecule	2 g	Intravenous
Subject	Methotrexate	Small molecule	4 mg/m2	Intravenous
Subject	Thiotepa	Other / unclassified	5 mg/kg	Intravenous
Subject	Thiotepa	Other / unclassified	40 mg/m2	Intravenous
Subject	carmustine	Small molecule	400 mg/m2	Intravenous

High-dose Chemotherapy and Stem Cell Transplantation for Central Nervous System (CNS) Relapse of Aggressive Lymphomas

Summary

Timeline

Publications

Drugs

Indications