drugset / Trial / NCT01529177
Metformin for the Treatment of Unexplained Oligozspermia
RandomizedParallel-groupOpen-labelTreatment
Summary
Insulin resistance (IR) in men may be the underlying pathogenesis for metabolic abnormalities and chronic hypospermatogenesis similar to women with polycystic ovarian disease (PCOD). Infertile men with unexplained infertility and IR may benefit from treatment with metformin.
Timeline
- Start
- 2012-02
- Primary completion
- 2016-09
- Completion
- 2017-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clomiphene | Other / unclassified | 50 mg | Oral |
| Subject | Metformin | Small molecule | 1000 mg | Oral |
| Subject | human chorionic gonadotropin | Protein / enzyme biologic | 5000 iu | Intramuscular |