Painless Local Infiltration Anesthesia

Phase 4 Completed 100 enrolled Campus-Bio-Medico University

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to assess if a dilution with 1.4% sodium bicarbonate of a 2% mepivacaine+epinephrine solution, can be effective in reducing the pain associated with local infiltration anesthesia, during ambulatory phlebectomy procedures.

Timeline

Start: 2012-05
Primary completion: 2012-12
Completion: 2012-12

Publications

Background Creton D, Rea B, Pittaluga P, Chastanet S, Allaert FA. Evaluation of the pain in varicose vein surgery under tumescent local anaesthesia using sodium bicarbonate as excipient without any intravenous sedation. Phlebology. 2012 Oct;27(7):368-73. doi: 10.1258/phleb.2011.011026. Epub 2011 Nov 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium bicarbonate	Diagnostic / imaging agent	16 ml	Other
Comparator	sodium chloride	Unknown	16 ml	Other
Background	Epinephrine	Other / unclassified	20 ug	Other
Background	Mepivacaine	Other / unclassified	80 mg	Other

Painless Local Infiltration Anesthesia

Summary

Timeline

Publications

Drugs

Indications