Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
Summary
The purpose of this study is to determine the effectiveness of buffered local anesthesia injections to numb the gums and teeth during dental treatment. Adjusting the pH of lidocaine with sodium bicarbonate may reduce the pain of injection for both adults and children. In this study, the investigators will compare two local anesthetic preparations, a buffered anesthetic and the conventionally available anesthetic, for pain upon injection. Hypothesis: Anesthetic buffered to physiologic pH will result in a less painful injection compared to the acidic alternative used in most dental offices. This can be demonstrated by comparing two local anesthetic preparations, a buffered anesthetic and the conventionally available anesthetic, for pain upon injection.
Timeline
- Start
- 2012-04
- Primary completion
- 2012-07
- Completion
- 2013-07
Publications
- Background Milgrom P, Coldwell SE, Getz T, Weinstein P, Ramsay DS. Four dimensions of fear of dental injections. J Am Dent Assoc. 1997 Jun;128(6):756-66. doi: 10.14219/jada.archive.1997.0301.
- Background Cepeda MS, Tzortzopoulou A, Thackrey M, Hudcova J, Arora Gandhi P, Schumann R. Adjusting the pH of lidocaine for reducing pain on injection. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD006581. doi: 10.1002/14651858.CD006581.pub2.
- Background von Baeyer CL. Children's self-report of pain intensity: what we know, where we are headed. Pain Res Manag. 2009 Jan-Feb;14(1):39-45. doi: 10.1155/2009/259759.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | sodium bicarbonate | Diagnostic / imaging agent | 8.4 % | Other |
| Background | Epinephrine | Other / unclassified | — | Other |
| Comparator | Lidocaine | Other / unclassified | 2 % | Other |
Indications
No indication recorded.