drugset / Trial / NCT01667445

Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty

NCT01667445

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to determine the contribution of spinal epimorph to patient's perioperative pain management in Total Knee Arthroplasty (TKA). This study is designed to determine whether spinal epimorph and its associated complications is a necessary addition to provide adequate analgesia given the multimodal approach to pain management. It is hypothesized that perioperative local infiltration with a cocktail of local and systemic analgesics will provide equal analgesia to patients who are given both local infiltration and spinal epimorph perioperatively.

Timeline

Start
2012-09
Primary completion
2014-09
Completion
2014-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Morphine Other / unclassified 150 ug Intrathecal
Subject Morphine Other / unclassified 10 mg Intrathecal
Background Epinephrine Other / unclassified 275 ug Other
Background Ketorolac Other / unclassified 30 mg Other
Background Ropivacaine Other / unclassified 385 ug Other

Indications