drugset / Trial / NCT01828489
Research Study for Treatment of Children and Adolescents With Acute Myeloid Leukaemia 0-18 Years
RandomizedFactorialOpen-labelTreatment
Summary
This study evaluates the effect of different induction courses in children and adolescents with newly diagnosed acute myeloid leukemia. In the first course patients are randomised to receive either standard anthracycline therapy with mitoxantrone or experimental DaunoXome. In the second course patients are randomised between standard treatment with ADxE (cytarabine, DaunoXome, etoposide) or experimental therapy with FLADx (fludarabine, cytarabine, DaunoXome).
Timeline
- Start
- 2013-03
- Primary completion
- 2018-03
- Completion
- 2023-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Daunorubicin | Small molecule | — | — |
| Subject | Etoposide | Small molecule | — | — |
| Subject | Fludarabine | Small molecule | — | — |
| Subject | Mitoxantrone | Small molecule | — | — |
| Background | Cytarabine | Small molecule | — | — |