drugset / Trial / NCT02112448
Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
RandomizedParallel-groupDouble-blindTreatment
Summary
The investigators hypothesize that intermittent bolus doses of morphine and midazolam can provide the same pain control after pediatric cardiothoracic surgery as bolus doses plus infusions while using smaller total doses of both medications. The investigators will randomize patients to receive either morphine/midazolam as needed intermittently or morphine/midazolam drips plus intermittent doses to be received as needed. Pain scores will be recorded and total medications given will be recorded.
Timeline
- Start
- 2014-06
- Primary completion
- 2016-05
- Completion
- 2016-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Midazolam | Small molecule | 0.03 mg/kg | Intravenous |
| Comparator | Midazolam | Small molecule | 0.05 mg/kg | Intravenous |
| Comparator | Midazolam | Small molecule | 0.3 mg/kg | Intravenous |
| Comparator | Morphine | Other / unclassified | 0.03 mg/kg | Intravenous |
| Comparator | Morphine | Other / unclassified | 0.05 mg/kg | Intravenous |
| Comparator | Morphine | Other / unclassified | 0.3 mg/kg | Intravenous |
| Comparator | Acetaminophen | Small molecule | 15 mg/kg | Rectal |
| Comparator | Ketorolac | Other / unclassified | 0.5 mg/kg | Intravenous |