Comparison of Exparel to Bupivacaine With Dexamethasone in TAP Block
Summary
The purpose of this study is to compare the efficacy and duration of bupivacaine extended-release liposome injection (Exparel) versus bupivacaine with dexamethasone in transversus abdominis plane (TAP) blocks for patients undergoing abdominal surgery at Emory University Hospital and Emory University Hospital Midtown. The investigators hypothesize that Exparel will provide greater postoperative pain relief than bupivacaine with dexamethasone. The investigators plan to enroll up to 50 male and female subjects meeting inclusion and exclusion criteria who will be randomized to receive either Exparel (Group 1) or bupivacaine with epinephrine and dexamethasone (Group 2) in the TAP block to achieve at least 22 subjects in each group
Timeline
- Start
- 2014-07
- Primary completion
- 2015-06-06
- Completion
- 2015-06-06
Outcome
Outcome not reported
Stopped (Enrollment): “Inadequate patient population to complete enrollment”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Bupivacaine | Other / unclassified | 28 ml | Other |
| Comparator | Bupivacaine | Other / unclassified | 266 mg | Other |
| Comparator | Dexamethasone | Small molecule | 8 mg | Other |
| Comparator | Acetaminophen | Small molecule | 650 mg | Intravenous |
| Comparator | Acetaminophen | Small molecule | 1000 mg | Intravenous |
Indications
No indication recorded.