drugset / Trial / NCT02219581
Steroids in Total Knee Arthroplasty
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication. The investigators will also determine if the subjects receiving the steroid will have better pain control and better postoperative outcomes after their surgery.
Timeline
- Start
- 2014-10-16
- Primary completion
- 2015-12-01
- Completion
- 2015-12-01
Outcome
Outcome not reported
Stopped: “Terminated after considerable time in suspended state due to inadequate staffing, the COVID pandemic, and the Responsible Party leaving Emory in August 2022.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexamethasone | Small molecule | 10 mg | Intravenous |
| Subject | Dexamethasone | Small molecule | 20 mg | Intravenous |
| Background | Acetaminophen | Small molecule | 1000 mg | — |
| Background | Hydrocodone | Unknown | — | — |
| Background | Hydromorphone | Other / unclassified | — | Oral |
| Background | Ketorolac Tromethamine | Small molecule | 15 mg | — |
| Background | Ketorolac Tromethamine | Small molecule | 30 mg | — |
| Background | Morphine | Other / unclassified | 1 mg | Intravenous |
| Background | Morphine | Other / unclassified | 2 mg | Intravenous |
| Background | Oxycodone | Other / unclassified | 5 mg | — |
| Background | Oxycodone | Other / unclassified | 10 mg | — |
| Background | Ropivacaine | Other / unclassified | 300 mg | Subcutaneous |