drugset / Trial / NCT02405689
Myocardial Protection and Anesthetic Agents
RandomizedParallel-groupDouble-blindPrevention
Summary
The aim of this study was to investigate the myocardial protective effects of remifentanil and dexmedetomidine in cardiac surgery.
Timeline
- Start
- 2014-12
- Primary completion
- 2015-08
- Completion
- 2015-08
Publications
- Background Kapoor P, Mandal B, Chowdhury U, Singh S, Kiran U. Changes in myocardial lactate, pyruvate and lactate-pyruvate ratio during cardiopulmonary bypass for elective adult cardiac surgery: Early indicator of morbidity. J Anaesthesiol Clin Pharmacol. 2011 Apr;27(2):225-32. doi: 10.4103/0970-9185.81819.
- Background Triggiani M, Simeone F, Gallorini C, Paolini G, Donatelli F, Paolillo G, Dolci A, Grossi A. Measurement of cardiac troponin T and myosin to detect perioperative myocardial damage during coronary surgery. Cardiovasc Surg. 1994 Aug;2(4):441-5. doi: 10.1177/096721099400200402.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.3 ug/kg | — |
| Comparator | Dexmedetomidine | Other / unclassified | 0.9 ug/kg | — |
| Comparator | Remifentanil | Small molecule | 0.125 ug/kg | — |
| Comparator | Remifentanil | Small molecule | 0.25 ug/kg | — |
| Comparator | Sevoflurane | Other / unclassified | 0.5 % | — |
| Comparator | Sevoflurane | Other / unclassified | 1.5 % | — |