drugset / Trial / NCT02486926
The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children
RandomizedParallel-groupTriple-blindTreatment
Summary
Sevoflurane is widely and frequently used in pediatric anesthesia due to its non-irritating airway properties, rapid induction and emergence. However, it is associated with emergence agitation (EA) in children. EA may cause injury to the child or to the surgical site and is a cause of stress to both caregivers and families. Various pharmacologic agents have been suggested to reduce EA. But the effect of remifentanil on EA is still controversial. This study was designed to compare the effects of remifentanil and remifentanil combining alfentanil on EA in children undergoing ophthalmic surgery with sevoflurane anesthesia.
Timeline
- Start
- 2012-11
- Primary completion
- 2013-07
- Completion
- 2014-01
Publications
- Background Ozturk T, Erbuyun K, Keles GT, Ozer M, Yuksel H, Tok D. The effect of remifentanil on the emergence characteristics of children undergoing FBO for bronchoalveolar lavage with sevoflurane anaesthesia. Eur J Anaesthesiol. 2009 Apr;26(4):338-42. doi: 10.1097/EJA.0b013e32831de50d.
- Choi YH, Kim KM, Lee SK, Kim YS, Kim SJ, Hwang WS, Chung JH. Effects of remifentanil and remifentanil-alfentanil administration on emergence agitation after brief ophthalmic surgery in children. BMC Anesthesiol. 2016 Aug 2;16(1):50. doi: 10.1186/s12871-016-0213-2.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Alfentanil | Other / unclassified | 5 ug/kg | Intravenous |
| Subject | Remifentanil | Small molecule | 0.1 ug/kg | — |
| Background | Rocuronium | Other / unclassified | 0.6 mg/kg | — |
| Background | Thiopental | Small molecule | 5 mg/kg | — |
Indications
No indication recorded.