drugset / Trial / NCT02499445
Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery
RandomizedParallel-groupSingle-blindTreatment
Summary
In patients undergoing off-pump coronary artery bypass (OPCAB) surgery with different anesthesia regimens: remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site concentration 0.8-1.5 mcg/ml) (Group -RP); remifentanil (0.75 mcg/kg/min) and sevoflurane (end-tidal 0.8 vol%) (Group-RS), or sevoflurane (end-tidal 1.2-2.8 vol%)-sufentanil (TCI effect site concentration 0.35-0.75 ng/ml) (Group-SS), intergroup difference in the level of Troponin I (c-TnI) and creatinine kinase subtype-MB is determined before surgery (control), during vascular graft harvesting (harvesting), after completing graft construction (postgrafting), and one day after surgery (postoperative).
Timeline
- Start
- 2007-11
- Primary completion
- 2014-10
- Completion
- 2014-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 0.8 ug/ml | — |
| Comparator | Propofol | Small molecule | 1.5 ug/ml | — |
| Comparator | Remifentanil | Small molecule | 0.75 ug/kg | — |
| Comparator | Sevoflurane | Other / unclassified | 0.8 % | — |
| Comparator | Sufentanil | Other / unclassified | 0.35 ng/ml | — |
| Comparator | Sufentanil | Other / unclassified | 0.75 ng/ml | — |