drugset / Trial / NCT02574728
Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors
Phase 2
Active not recruiting
46 enrolled
Emory University
Cannonball Kids' Cancer Foundation · collabHyundai Hope On Wheels · collab
NaSingle-groupOpen-labelTreatment
Summary
This study aims to determine the efficacy of daily sirolimus and celecoxib, with low dose etoposide alternating with cyclophosphamide for pediatric participants with relapsed or refractory tumors.
Timeline
- Start
- 2015-06
- Primary completion
- 2026-06
- Completion
- 2026-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Celecoxib | Other / unclassified | 100 mg | Oral |
| Subject | Cyclophosphamide | Other / unclassified | 2.5 mg/kg | Oral |
| Subject | Etoposide | Small molecule | 50 mg/m2 | Oral |
| Subject | Sirolimus | Small molecule | 2 mg/m2 | Oral |