drugset / Trial / NCT02813044

Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor

NCT02813044

Completed 82 enrolled Yonsei University
RandomizedParallel-groupDouble-blindOther

Summary

A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery. However, they have limitations especially for the phase of recovery after anesthesia: a fragmentary assessment. Quality of Recovery 40 (QoR-40) questionnaire was multi-dimensionally designed to assess the degree of recovery, specially after anesthesia and surgery. In this study, the investigators aim to compare the quality of recovery after inhalational anesthesia and after TIVA through QoR-40 questionnaire in patients undergoing transsphenoidal surgery for pituitary tumor under general anesthesia.

Timeline

Start
2016-06-16
Primary completion
2018-06-15
Completion
2018-06-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Propofol Small molecule Intravenous
Comparator Sevoflurane Other / unclassified 0.8 unknown Inhaled
Comparator Sevoflurane Other / unclassified 1 unknown Inhaled
Background Remifentanil Small molecule 0.1 ug/kg Intravenous
Background Remifentanil Small molecule 0.3 ug/kg Intravenous
Comparator Thiopental Small molecule 4 mg/kg
Comparator Thiopental Small molecule 6 mg/kg

Indications