drugset / Trial / NCT02935933
Paravertebral Morphine Versus Dexmedetomidine on Acute and Chronic Postmastectomy Pain
RandomizedParallel-groupDouble-blindTreatment
Summary
Evaluate the effect of addition of morphine, dexmedetomidine to bupivacaine in PVB could improve the analgesic effect and thus reduce postoperative morphine consumption and development of chronic neuropathic pain, compared to PVB with bupivacaine , in patients undergoing major breast cancer surgery, i.e., modified radical mastectomy (MRM) and breast conservation surgery with axillary lymph node dissection.
Timeline
- Start
- 2016-10
- Primary completion
- 2017-09
- Completion
- 2018-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 1 ug/kg | Other |
| Comparator | Morphine | Other / unclassified | 5 mg | Other |
| Comparator | Bupivacaine | Other / unclassified | 0.25 % | Other |
| Comparator | Bupivacaine | Other / unclassified | 20 ml | Other |