drugset / Trial / NCT03084536
PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery
RandomizedParallel-groupQuadruple-blindTreatment
Summary
In this double blinded randomized placebo-controlled trial, 160 subjects scheduled for breast surgery involving the axilla will be administered a multimodal pain regimen including acetaminophen, dexamethasone, celecoxib, and gabapentin. 80 subjects will also receive a Pectoral Nerve blocks I and II (PECS I and II block) preoperatively.
Timeline
- Start
- 2017-06-07
- Primary completion
- 2021-02-25
- Completion
- 2021-02-25
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Bupivacaine | Other / unclassified | 0.375 % | — |
| Comparator | Acetaminophen | Small molecule | 1000 mg | — |
| Comparator | Celecoxib | Other / unclassified | 200 mg | — |
| Comparator | Fentanyl | Other / unclassified | 50 ug | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 100 ug | Intravenous |
| Comparator | Gabapentin | Small molecule | 300 mg | — |
| Comparator | Midazolam | Small molecule | 1 mg | Intravenous |
| Comparator | Midazolam | Small molecule | 2 mg | Intravenous |