drugset / Trial / NCT03096730
Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia
RandomizedParallel-groupDouble-blindPrevention
Summary
To explore and compare antihyperalgesic effects of Dexmedetomidine,Nalmefene,and a combination of both received before anesthesia induction. To evaluate and examine the incidence of adverse effects with the purpose of selecting the optimum dose.
Timeline
- Start
- 2017-02-06
- Primary completion
- 2017-12-20
- Completion
- 2017-12-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.25 ug/kg | Intravenous |
| Comparator | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | Intravenous |
| Comparator | Nalmefene | Small molecule | 0.1 ug/kg | Intravenous |
| Comparator | Nalmefene | Small molecule | 0.2 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | — | Intravenous |
| Comparator | Sufentanil | Other / unclassified | — | Intravenous |
Indications
No indication recorded.