drugset / Trial / NCT03484507
Parasitic Ulcer Treatment Trial Pilot
Phase 2
Completed
49 enrolled
University of California, San Francisco
Research to Prevent Blindness · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine. After four weeks of therapy, participants will be re-randomized to early corticosteroids, later corticosteroids, or placebo.
Timeline
- Start
- 2018-01-01
- Primary completion
- 2022-11-15
- Completion
- 2022-11-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Chlorhexidine | Small molecule | 0.04 % | Topical |
| Subject | Povidone-Iodine | Other / unclassified | 2.5 % | Topical |
| Subject | Prednisolone | Other / unclassified | 1 % | Topical |