Analgesic Efficacy of Adding SCB With Low Concentration Bupivacaine Combined With Dexamethasone on Pain After TKA

Phase 4 Unknown 50 enrolled Mahidol University

RandomizedParallel-groupTriple-blindTreatment

Summary

This study evaluate the efficacy of adding popliteal sciatic nerve block with low concentration bupivacaine and dexamethasone to abductor canal block for total knee arthroplasty in patient with NSAIDs prescribing precaution. Half of participants will receive popliteal sciatic nerve block, abductor canal block and periarticular injection, while the other half will receive a sham block, abductor canal block and periarticular injection.

Timeline

Start: 2018-04
Primary completion: 2019-02
Completion: 2019-02

Publications

Sirivanasandha B, Sutthivaiyakit K, Kerdchan T, Poolsuppasit S, Tangwiwat S, Halilamien P. Adding a low-concentration sciatic nerve block to total knee arthroplasty in patients susceptible to the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs): a randomized controlled trial. BMC Anesthesiol. 2021 Nov 13;21(1):282. doi: 10.1186/s12871-021-01491-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	0.125 %	—
Subject	Bupivacaine	Other / unclassified	0.33 %	—
Subject	Bupivacaine	Other / unclassified	15 ml	—
Subject	Bupivacaine	Other / unclassified	20 ml	—
Subject	Dexamethasone	Small molecule	5 mg	—
Comparator	Lidocaine	Other / unclassified	1 ml	Subcutaneous
Comparator	Lidocaine	Other / unclassified	2 %	Subcutaneous

Indications

No indication recorded.