drugset / Trial / NCT04680650
Comparison of Anesthesia Effects of Sevoflurane and Propofol Combined With Dexmedetomidine in Intraoperative Neuromonitoring During Thyroidectomy
RandomizedParallel-groupDouble-blindTreatment
Summary
According to the previous studies, it is reported that the use of sevoflurane in the maintenance of anesthesia may lead to delayed occurrence of positive electromyographic (EMG) signal and lower obtained signal amplitude. In this study, the investigators aimed to investigate the anesthetic effect of sevoflurane combined with dexmedetomidine for neuromonitoring during thyroid surgery. The investigators hypothesize that sevoflurane combined with dexmedetomidine can reduce the movement or spontaneous activity of vocal cords in patients and without affecting the EMG signals.
Timeline
- Start
- 2020-04-30
- Primary completion
- 2021-03-31
- Completion
- 2021-03-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 2 ug/ml | — |
| Comparator | Propofol | Small molecule | 4 ug/ml | — |
| Subject | Sevoflurane | Other / unclassified | 1.5 % | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 3 % | Inhaled |
| Background | Dexmedetomidine | Other / unclassified | 0.3 ug/kg | — |
| Background | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | — |
| Background | Remifentanil | Small molecule | 2 ug/ml | — |
| Background | Remifentanil | Small molecule | 4 ug/ml | — |