drugset / Trial / NCT04802122

Induction of Anesthesia With Sevoflurane Preserving Spontaneous Breathing: Cardiorespiratory Effects.

NCT04802122

Phase 4 Completed 60 enrolled Aristotle University Of Thessaloniki
RandomizedParallel-groupOpen-labelTreatment

Summary

Airway management is of outmost importance in the perioperative period. One of the main questions while making a plan for airway management is whether spontaneous ventilation should be maintained or not. Induction of anesthesia with Sevoflurane is a conventional technique that preserves spontaneous ventilation. It is used especially in non-collaborating patients or when other pharmaceutical agents or sophisticated airway management equipment is out of reach. Inhalational induction of anesthesia with Sevoflurane is well studied. However, there are few studies investigating the effects of Sevoflurane on induction and intubating conditions, on cardiopulmonary physiology, on emergence conditions, when it is used as one and only agent to achieve induction of anesthesia, intubation and maintenance of anesthesia in adult patients. There is also no consensus on the appropriate duration of the inhalational induction or other criteria to guarantee successful intubation conditions, since most studies investigate Sevoflurane administration until induction of anesthesia and not until intubation. From all the above, it appears that there are a few gaps in the management of patients who are to be intubated with Sevoflurane only, without the use of any other anesthetic agents.

Timeline

Start
2021-05-24
Primary completion
2021-07-13
Completion
2021-07-14

Drugs

EvaluationDrugModalityDoseRoute
Comparator Propofol Small molecule 1.5 mg/kg
Subject Sevoflurane Other / unclassified 1 unknown Inhaled
Comparator Fentanyl Other / unclassified 2 ug/kg
Comparator Rocuronium Other / unclassified 0.5 mg/kg

Indications

No indication recorded.