Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy

Summary

To determine if opioid consumption postoperatively among patients undergoing non-emergent laparotomy by the gynecologic oncology service who receive intrathecal morphine with intraoperative lidocaine (IML) infusion are lower than patients who have epidural anesthesia with PCA (EPCA).

Timeline

Start

2022-01-18

Primary completion

2024-07-17

Completion

2024-08-29

Outcome

Met primary endpoint

Stopped (Enrollment): “Low accrual”

registry analysis (superiority test); Epidural Bupivacaine With Hydromorphone Patient-controlled Anesthesia (EPCA) vs Intrathecal Morphine With Intraoperative Lidocaine Infusion; p = 0.0249; NCT05017246 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bupivacaine	Other / unclassified	0.1 %	Other
Subject	Lidocaine	Other / unclassified	1 mg/kg	—
Subject	Morphine	Other / unclassified	0.15 mg	Other

Indications