Public Health Emergency: SOLIDARITY TRIAL Philippines

Completed 1314 enrolled University of the Philippines

RandomizedParallel-groupOpen-labelTreatment

Summary

This study is an adaptive, randomized, open-label, controlled clinical trial utilizing an adaptive design to compare effects of repurposed drugs with local standard of care alone on major inpatient hospital outcomes. This is performed worldwide in collaboration with WHO.

Timeline

Start: 2020-04-23
Primary completion: 2021-04-17
Completion: 2021-04-17

Publications

Grundeis F, Ansems K, Dahms K, Thieme V, Metzendorf MI, Skoetz N, Benstoem C, Mikolajewska A, Griesel M, Fichtner F, Stegemann M. Remdesivir for the treatment of COVID-19. Cochrane Database Syst Rev. 2023 Jan 25;1(1):CD014962. doi: 10.1002/14651858.CD014962.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acalabrutinib	Small molecule	—	Oral
Subject	Hydroxychloroquine	Small molecule	—	Oral
Subject	Interferon beta-1a	Protein / enzyme biologic	—	Other
Subject	Lopinavir	Other / unclassified	—	Oral
Subject	Remdesivir	Small molecule	—	Intravenous
Subject	Ritonavir	Other / unclassified	—	Oral

Public Health Emergency: SOLIDARITY TRIAL Philippines

Summary

Timeline

Publications

Drugs

Indications