drugset / Trial / NCT05036226
COAST Therapy in Advanced Solid Tumors and Prostate Cancer
Non-randomizedSequentialOpen-labelTreatment
Summary
The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers. The drugs are hydroxychloroquine, metformin, sirolimus, dasatinib and nelfinavir and are given orally.
Timeline
- Start
- 2022-03-03
- Primary completion
- 2027-05-21
- Completion
- 2028-05-21
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Hydroxychloroquine | Small molecule | 600 mg | Oral |
| Subject | Metformin | Small molecule | 1000 mg | Oral |
| Subject | Nelfinavir | Other / unclassified | 1250 mg | Oral |
| Subject | Nelfinavir | Other / unclassified | 2500 mg | Oral |
| Subject | Sirolimus | Small molecule | 0.5 mg | Oral |
| Subject | dasatinib anhydrous | Small molecule | 20 mg | Oral |