drugset / Trial / NCT05157113
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
RandomizedCrossoverSingle-blindPrevention
Summary
The current postoperative cataract surgery eye drop regimen used at Zuckerberg San Francisco General Hospital (ZSFG) is a significant burden for its patient population, contributing to high rates of non-adherence and the development of postoperative complications. The investigators propose to replace this complex regimen with a single administration of intraocular antibiotic and subconjunctival steroid at the time of surgery. This pilot study will obtain the preliminary data required to eventually fully evaluate this innovation in postoperative care in a safety-net population with respect to postoperative outcomes, patient compliance, and patient and caregiver satisfaction.
Timeline
- Start
- 2022-05-31
- Primary completion
- 2026-06-01
- Completion
- 2026-06-01
Publications
- Background Shorstein NH, Liu L, Waxman MD, Herrinton LJ. Comparative Effectiveness of Three Prophylactic Strategies to Prevent Clinical Macular Edema after Phacoemulsification Surgery. Ophthalmology. 2015 Dec;122(12):2450-6. doi: 10.1016/j.ophtha.2015.08.024. Epub 2015 Sep 26.
- Background Shorstein NH, Winthrop KL, Herrinton LJ. Decreased postoperative endophthalmitis rate after institution of intracameral antibiotics in a Northern California eye department. J Cataract Refract Surg. 2013 Jan;39(1):8-14. doi: 10.1016/j.jcrs.2012.07.031. Epub 2012 Oct 2.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ketorolac | Other / unclassified | 0.5 % | Topical |
| Comparator | Neomycin | Unknown | — | Topical |
| Comparator | Polymyxin B | Peptide | — | Topical |
| Comparator | Prednisolone | Other / unclassified | 1 % | Topical |
| Comparator | Triamcinolone Acetonide | Other / unclassified | 20 mg | Other |
| Comparator | Cefuroxime | Small molecule | — | Other |