drugset / Trial / NCT05282251

Intrapleural Nebulization of Bupivacain to Reduce Postoperative Pain

NCT05282251

Unknown 60 enrolled Assiut University
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Thoracic surgery is now common and as other surgeries evolution of minimally invasive techniques is employed. Video-assisted thoracic surgery (VATS) produces little scar but may produce severe pain that may affect the pulmonary function. Many procedure was developed like intercostal nerve block which require injections at multiple levels, Insertion of local anaesthetic (LA) in the surgical drain but that was dangerous due to the large amount of LA and not sufficient to completely eliminate pain. Bupvicaine nebulization, through surgical port which won't make any other wound, thought to be sufficient because Nebulization will enable us better distribution and less amounts of LA. Bupvicaine is local anaesthetic amide group that works by blocking sodium channels thus preventing progression of action potential.

Timeline

Start
2024-05-17
Primary completion
2024-07-15
Completion
2024-07-15

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 1 g Intravenous
Subject Bupivacaine Other / unclassified 0.5 % Other
Subject Bupivacaine Other / unclassified 10 ml Other
Comparator Ketorolac Other / unclassified 30 mg Intravenous

Indications