Split Face Study of the Duration of Local Anesthetics
Summary
This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. This study will compare a short-acting anesthetic, lidocaine with epinephrine, to one of two long-acting anesthetics (ropivacaine or bupivacaine). This study will also directly compare the duration of actions of ropivacaine and bupivacaine. The investigators hypothesize that the duration of anesthesia of short-acting anesthetics will not differ significantly from long-acting anesthetics at a single site and there will not be a significant difference between the two long-acting anesthetics at a single site.
Timeline
- Start
- 2023-03-14
- Primary completion
- 2023-07-31
- Completion
- 2023-07-31
Outcome
Missed primary endpoint
registry analysis (superiority test); Lidocaine+Epinephrine (vs Ropivacaine) vs Lidocaine+Epinephrine (vs Bupivacaine); p = 0.93 NCT05767749 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupivacaine | Other / unclassified | 0.5 ml | Other |
| Subject | Bupivacaine | Other / unclassified | 0.5 % | Other |
| Subject | Lidocaine | Other / unclassified | 0.5 ml | Other |
| Subject | Ropivacaine | Other / unclassified | 0.5 ml | Other |
| Subject | Ropivacaine | Other / unclassified | 0.5 % | Other |
| Background | Epinephrine | Other / unclassified | — | Other |
Indications
No indication recorded.