The Efficacy of Using Pentoxifylline in Patients Undergoing Breast Cancer Surgery

Summary

The goal of this clinical trial is to assess the efficacy of pentoxifylline in reducing postsurgical complications for breast cancer patients undergoing breast cancer surgery. It aims to evaluate the efficacy of pentoxifylline on postoperative pain and wound healing.

Timeline

Start

2023-10-30

Primary completion

2024-06-30

Completion

2024-06-30

Outcome

Met primary endpoint

paper Patients receiving pentoxifylline demonstrated a significant decrease in NRS scores as compared to the control group PMID 40741002 ↗

paper were 90 (73.5-102), and 153 (123-168), respectively (P < 0.001) PMID 40741002 ↗

Publications

• Dewidar SA, Mansour NO, Hamdy O, Elebedy DA, Soliman MM, Shams MEE. Efficacy of using pentoxifylline in patients undergoing breast cancer surgery. Front Pharmacol. 2025 Jul 16;16:1560805. doi: 10.3389/fphar.2025.1560805. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pentoxifylline	Small molecule	400 mg	Oral
Comparator	Acetaminophen	Small molecule	1 g	Intravenous
Comparator	Ketorolac	Other / unclassified	30 mg	Intravenous

Indications