Total Intravenous Anesthesia Versus Inhalation Anesthesia on Postoperative Liver Function

Completed 80 enrolled Benha University

RandomizedParallel-groupOpen-labelPrevention

Summary

The pandemic of obesity has become a serious issue of public health worldwide as the size of the obese population has almost tripled over the last four decades and continues to riseزThe epidemic of obesity has led to a significant increase in the prevalence of non-alcoholic fatty liver disease (NAFLD). NAFLD is currently the most common chronic liver disease, with an estimated global prevalence at 25-30%, rising up to 90% in morbidly obese patients

Timeline

Start: 2024-01-26
Primary completion: 2024-05-06
Completion: 2024-05-12

Publications

Background Ahmed OT, Gidener T, Mara KC, Larson JJ, Therneau TM, Allen AM. Natural History of Nonalcoholic Fatty Liver Disease With Normal Body Mass Index: A Population-Based Study. Clin Gastroenterol Hepatol. 2022 Jun;20(6):1374-1381.e6. doi: 10.1016/j.cgh.2021.07.016. Epub 2021 Jul 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	0.1 ug/kg	—
Subject	Fentanyl	Other / unclassified	1 ug/kg	—
Subject	Propofol	Small molecule	200 ug/kg	Intravenous
Subject	Propofol	Small molecule	2 mg/kg	Intravenous
Subject	Sevoflurane	Other / unclassified	—	Inhaled
Background	Dexmedetomidine	Other / unclassified	1 ug/kg	—

Indications

No indication recorded.