drugset / Trial / NCT07000058

Wide-Awake Local Anesthesia No Tourniquet (WALANT) With Versus Without Hyaluronidase for Hand Surgery

NCT07000058

Phase 2/3 Active not recruiting 100 enrolled Misr University for Science and Technology
RandomizedParallel-groupTriple-blindTreatment

Summary

The WALANT (Wide Awake Local Anesthesia No Tourniquet) method, introduced by Dr. Donald H. Lalonde over a decade ago, has gained popularity due to its favorable outcomes and patient satisfaction. This technique involves injecting diluted lidocaine and epinephrine, which helps control pain and bleeding without the discomfort of a tourniquet. This research will explore the use of hyaluronidase to enhance the WALANT technique. The study hypothesize that adding hyaluronidase would improve the onset speed and duration of pain control. A double-blinded study involving 100 patients compared WALANT with hyaluronidase (Group A) to WALANT without Hyaluronidase (Group B).

Timeline

Start
2025-06-20
Primary completion
2025-12-31
Completion
2025-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject rHuPH20 Protein / enzyme biologic 15 iu Subcutaneous
Comparator Epinephrine Other / unclassified Subcutaneous
Comparator Lidocaine Other / unclassified 1 % Subcutaneous
Comparator sodium bicarbonate Diagnostic / imaging agent 8.4 % Subcutaneous

Indications

No indication recorded.