drugset / Trial / NCT07145879
Comparison of Postoperative Effects of Articaine and Lidocaine in Mucogingival Surgery
RandomizedFactorialDouble-blindDiagnostic
Summary
The aim of this study is to compare and evaluate the effects of using lidocaine 2% (with adrenaline) and articaine 4% (with adrenaline) in free gingival graft (FGG) surgery on postoperative wound healing, changes in blood flow in the surgical area during the healing process, patients' postoperative pain levels, and anxiety levels before and after surgery.
Timeline
- Start
- 2025-01-01
- Primary completion
- 2025-07-30
- Completion
- 2025-07-30
Publications
- Background Kesici S, Kesici U, Ulusoy H, Erturkuner P, Turkmen A, Arda O. [Effects of local anesthetics on wound healing]. Braz J Anesthesiol. 2018 Jul-Aug;68(4):375-382. doi: 10.1016/j.bjan.2018.01.016. Epub 2018 Jun 6.
- Background Al-Saffar, M.T., A.S. Mahmood, and M.S. Sulaiman, Impact of Local Anesthesia on Wound Healing. Indian Journal of Forensic Medicine & Toxicology, 2020. 14(4): p. 1869-1874.
- Background Giovannitti JA Jr, Rosenberg MB, Phero JC. Pharmacology of local anesthetics used in oral surgery. Oral Maxillofac Surg Clin North Am. 2013 Aug;25(3):453-65, vi. doi: 10.1016/j.coms.2013.03.003. Epub 2013 May 7.
- Background Luo W, Zheng K, Kuang H, Li Z, Wang J, Mei J. The potential of articaine as new generation of local anesthesia in dental clinics: A review. Medicine (Baltimore). 2022 Dec 2;101(48):e32089. doi: 10.1097/MD.0000000000032089.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Articaine | Other / unclassified | 40 mg/ml | Other |
| Subject | Lidocaine | Other / unclassified | 20 mg/ml | Other |
| Background | Epinephrine | Other / unclassified | 0.012 mg/ml | Other |