drugset / Trial / NCT07169227
Lidocaine, Paracetamol, and Dexmedetomidine for Rocuronium Injection Pain
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Propofol and rocuronium may cause pain during intravenous injection. Various pharmacological agents are used to reduce the incidence and severity of injection pain. Among the most commonly used agents for this purpose are lidocaine, various opioids, ketamine, paracetamol, and dexmedetomidine. The aim of this study was to evaluate the comparative effect of intravenous dexmedetomidine and paracetamol versus lidocaine in preventing propofol- and rocuronium-induced pain during anesthesia induction.
Timeline
- Start
- 2025-09
- Primary completion
- 2025-10
- Completion
- 2025-10
Publications
- Results Uzun S, Erden IA, Canbay O, Aypar U. The effect of intravenous paracetamol for the prevention of rocuronium injection pain. Kaohsiung J Med Sci. 2014 Nov;30(11):566-9. doi: 10.1016/j.kjms.2014.08.002. Epub 2014 Sep 22.
- Results He L, Xu JM, He T, Liu L, Zhu R. Dexmedetomidine pretreatment alleviates propofol injection pain. Ups J Med Sci. 2014 Nov;119(4):338-42. doi: 10.3109/03009734.2014.941049. Epub 2014 Oct 24.
- Results Kwak HJ, Kim JY, Kim YB, Min SK, Moon BK, Kim JY. Pharmacological prevention of rocuronium-induced injection pain or withdrawal movements: a meta-analysis. J Anesth. 2013 Oct;27(5):742-9. doi: 10.1007/s00540-013-1595-7. Epub 2013 Mar 22.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 50 mg | Intravenous |
| Subject | Dexmedetomidine | Other / unclassified | 0.25 mg/kg | Intravenous |
| Comparator | Lidocaine | Other / unclassified | 40 mg | — |
Indications
No indication recorded.