drugset
drugset / Trial / NCT07644923

Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

NCT07644923 ↗

Phase 4 Not yet recruiting 40 enrolled NYU Langone Health
RandomizedParallel-groupSingle-blindSupportive care

Summary

This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics. All surgical created wounds for any hand surgery will be treated in a randomized fashion with the following four arms: 1. Bupivacaine + lidocaine 2. Bupivacaine + lidocaine + thrombin 3. Bupivacaine + lidocaine + thrombin + tranexamic acid 4. Bupivacaine + lidocaine + thrombin + aminocaproic acid All are applied topically to surgical bed prior to closure of skin.

Timeline

Start
2026-08-01
Primary completion
2028-08-01
Completion
2029-02-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Aminocaproic Acid Small molecule 1000 mg Topical
Subject Tranexamic Acid Small molecule 500 mg Topical
Subject thrombin Protein / enzyme biologic 10000 iu Topical
Background Bupivacaine Other / unclassified 0.25 % Topical
Background Bupivacaine Other / unclassified 5 ml Topical
Background Lidocaine Other / unclassified 1 % Topical
Background Lidocaine Other / unclassified 5 ml Topical

Indications

No indication recorded.