Drugs / HLX43

Trials 17 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT06115642 Nov 2023 → Jun 2026 overdue metastatic malignant neoplasm Shanghai Henlius Biotech Enrolling by invitation No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT07358585 Jan 2026 → Jul 2027 expected colon adenocarcinoma Shanghai Henlius Biotech Not yet recruiting No outcome recorded
Phase 1/2 NCT06848699 Feb 2025 → Oct 2026 expected non-small cell lung carcinoma Shanghai Henlius Biotech Recruiting No outcome recorded
Phase 213 trials
Phase 2 NCT07487519 Apr 2026 → May 2027 expected triple-negative breast carcinoma Shanghai Henlius Biotech Not yet recruiting No outcome recorded
Phase 2 NCT07459738 Apr → Dec 2026 expected hormone receptor-positive breast cancer Shanghai Henlius Biotech Not yet recruiting No outcome recorded
Phase 2 NCT07269782 Jan → Jul 2026 overdue non-small cell lung carcinoma Shanghai Henlius Biotech Recruiting No outcome recorded
Phase 2 NCT07253142 Jan 2026 → Jun 2027 expected non-small cell lung carcinoma, small cell lung carcinoma Shanghai Henlius Biotech Not yet recruiting No outcome recorded
Phase 2 NCT07301229 Dec 2025 → Feb 2028 expected pancreatic ductal adenocarcinoma Shanghai Henlius Biotech Not yet recruiting No outcome recorded
Phase 2 NCT07115485 Sep 2025 → Aug 2027 expected gastroesophageal adenocarcinoma Shanghai Henlius Biotech Recruiting No outcome recorded
Phase 2 NCT07106892 Sep 2025 → Dec 2026 expected colorectal cancer Shanghai Henlius Biotech Recruiting No outcome recorded
Phase 2 NCT06907615 Jun 2025 → Apr 2028 expected non-small cell lung carcinoma Shanghai Henlius Biotech Recruiting No outcome recorded
Phase 2 NCT06857279 Apr 2025 → Dec 2027 expected head and neck carcinoma Shanghai Henlius Biotech Recruiting No outcome recorded
Phase 2 NCT06839066 Apr 2025 → Nov 2026 expected nasopharyngeal carcinoma Shanghai Henlius Biotech Recruiting No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07459751 May 2026 → Jan 2030 expected non-small cell squamous lung carcinoma Shanghai Henlius Biotech Recruiting No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 17 sources stand behind the page.

FieldValueCited text
Known as HLX43 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06907615
16

NCT06857279

NCT06742892

NCT07106892

NCT06115642

NCT06848699

NCT07459738

NCT07269782

NCT07253142

NCT07358585

NCT07301229

NCT07115485

NCT06769113

NCT07459751

NCT06769152

NCT07487519

NCT06839066

Action Inhibit “HLX43 is an anti-PD-L1 monoclonal antibody conjugated with a novel high potency DNA topoisomerase I (topo I) inhibitor, with a drug-antibody-ratio (DAR) of 8.” NCT06742892
Modality Other / unclassified “HLX43 (Anti-PD-L1 ADC)” NCT06115642
Route Intravenous “administered with HLX43 at different doses via intravenous infusion” NCT06115642