Drugs / PHOSPHINE SILANE
PHOSPHINE SILANE
also known as
Calcium Sodium Phosphosilicate · CSPS · Novamin · 45s5 bioglass · Bioactive Glass · Novamin technology · Perioglas
Trials 6
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 23 trials · 1 missed | ||||||
| Phase 2 | NCT01831817 | Jan → May 2013 | dentin sensitivity | GlaxoSmithKline | Completed | Missed primary |
| Phase 2 | NCT01691560 | Aug → Nov 2012 | dentin sensitivity | GlaxoSmithKline | Completed | Mixed |
| Phase 2 | NCT01657877 | May 2012 → Jun 2013 | dental caries | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT06608368 | Oct → Nov 2024 | dentin sensitivity | HALEON | Completed | No outcome recorded |
| Phase not applicable2 trials · 1 met primary | ||||||
| — | NCT07396610 | Jan → Mar 2025 | dentin sensitivity | King Khalid University | Completed | No outcome recorded |
| — | NCT06378008 | Apr → Sep 2024 | dentin sensitivity | HALEON | Completed | Met primary |
| Comparator or background therapy6 trials | ||||||
| Phase 1 | NCT06273930 Comparator | Feb → Oct 2024 | dentin sensitivity | Armed Forces Institute of Dentistry, Pakistan | Unknown | No outcome recorded |
| Phase 2 | NCT02918617 Comparator | May 2015 → Sep 2016 | dentin sensitivity | The University of Texas Health Science Center at San Antonio | Completed | No outcome recorded |
| Phase 3 | NCT07664592 Comparator | Jun → Jul 2026 overdue | dentin sensitivity | Colgate Palmolive | Recruiting | No outcome recorded |
| Phase 3 | NCT04401280 Comparator | Jun 2020 → Jun 2021 | smooth surface dental caries | Rania Salah | Completed | No outcome recorded |
| Phase 4 | NCT04767243 Comparator | Dec 2020 → Feb 2022 | bone resorption disease, chronic periodontitis | Maharishi Markendeswar University (Deemed to be University) | Completed | No outcome recorded |
| — | NCT05750745 Comparator | May → Sep 2023 | dentin sensitivity | HALEON | Completed | Missed primary |
Press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2011-03-01 | GlaxoSmithKline | World’s first everyday fluoride toothpaste with NovaMin® technology that can repair sensitive teeth gsk.com ↗ |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 14 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | PHOSPHINE SILANE | ChEMBL registry synonym — accepted as the source's own label CHEMBL6068763 ↗ |
| Known as | 45s5 bioglass | ChEMBL registry synonym — accepted as the source's own label CHEMBL6068763 ↗ |
| Known as | Bioactive Glass | “Bioactive Glass (NovaMin)” NCT07396610 ↗ |
| Known as | Calcium Sodium Phosphosilicate | “Anhydrous toothpastes containing 5% calcium-sodium phosphosilicate (CSPS) have well-established long-term efficacy against dentine hypersensitivity (DH).” PMID 42013973 ↗ Apr 20268“Dentifrice containing 5% w/w NovaMin (Calcium Sodium Phosphosilicate) and 1040 ppm fluoride as sodium fluoride.” NCT06608368 ↗ “Sensodyne Repair and Protect toothpaste is containing 5.0% w/w calcium sodium phosphosilicate (CSPS).” NCT05750745 ↗ “a commercial desensitizing dentifrice containing calcium sodium phosphosilicate (Novamin® technology)” NCT02918617 ↗ |
| Known as | CSPS | “Anhydrous toothpastes containing 5% calcium-sodium phosphosilicate (CSPS) have well-established long-term efficacy against dentine hypersensitivity (DH).” PMID 42013973 ↗ Apr 20262“Sensodyne Repair and Protect toothpaste is containing 5.0% w/w calcium sodium phosphosilicate (CSPS).” NCT05750745 ↗ “A commercially available fluoride toothpaste containing 5% Calcium Sodium Phosphosilicate (CSPS)” NCT07664592 ↗ |
| Known as | Novamin | “Dentifrice containing 5% w/w NovaMin (Calcium Sodium Phosphosilicate) and 1040 ppm fluoride as sodium fluoride.” NCT06608368 ↗ |
| Known as | Novamin technology | “a commercial desensitizing dentifrice containing calcium sodium phosphosilicate (Novamin® technology)” NCT02918617 ↗ |
| Known as | Perioglas | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04767243 ↗ |
| Modality | Other / unclassified | “particulate, bioactive glass material” NCT06273930 ↗ |
| Route | Topical | “Participants will dose the toothbrush with a ribbon of toothpaste, across the full brush head and will brush the entire dentition thoroughly” NCT06378008 ↗ |