Sodium Thiosulfate
Diagnostic / imaging agent targets ACE2, TMPRSS2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | EU (EMA) | Pedmarqsi | — | 2023-05-26 | europa.eu ↗ |
| Approved | US (FDA) | SODIUM THIOSULFATE | — | 1992-02-14 | fda.gov ↗ |
Trials 34 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 24 trials
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 61 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Sodium Thiosulfate | “Sodium thiosulfate has previously been reported to reduce the incidence of acute kidney injury after HIPEC with cisplatin, but this finding has not been confirmed in a high-level study.” NCT05877911 ↗54“Sodium thiosulfate (STS) is currently used as a cyanide poisoning antagonist and a chemoprotectant against adverse effects of several chemotherapies such as Cisplatin.” NCT03582800 ↗ “During interval surgery the patient will undergo HIPEC (Cisplatin 100mg/m2, 1h 30 infusions with sodium thiosulfate renal protection).” NCT04282356 ↗ “Pedmark® sodium thiosulfate (STS) in reducing hearing impairment with standard of care cisplatin therapy.” NCT07407582 ↗ “sodium thiosulfate 25% will be administered prior to each PIPAC procedure” NCT04811703 ↗ “along with an IV perfusion of sodium thiosulfate” NCT03842982 ↗ |
| Known as | DB-020 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04262336 ↗ |
| Known as | Pedmark | “receiving sodium thiosulfate anhydrous (Pedmark) plus cisplatin-based chemotherapy compared to those receiving cisplatin-based chemotherapy alone.” NCT07218913 ↗ |
| Known as | Seacalphyx | “Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25%” NCT04292184 ↗ |
| Known as | Sodium thiosulfate (STS) | “Sodium thiosulfate (STS)” NCT04292184 ↗ |
| Known as | sodium thiosulfate anhydrous | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07218913 ↗ |
| Known as | sodium thiosulfate pentahydrate injection BP | “Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25%” NCT04292184 ↗ |
| Known as | sodium thiosulphate | “Arm II (Neoadjuvant and adjuvant cisplatin and sodium thiosulphate): Patients receive cisplatin IV over 6 hours and sodium thiosulphate IV over 15 minutes (beginning 6 hours...” NCT00652132 ↗2“Another possibility is the use of sodium thiosulphate (Na2S2O3, STS), a major metabolite of H2S, commercially available compound and typically available as the pentahydrate,...” NCT04292184 ↗ |
| Known as | STS | “Efficacy of Sodium Thiosulfate (STS) compared to placebo, in reducing analgesic requirement in subjects with calcific uremic arteriolopathy (CUA) during an initial 28-day...” NCT02527213 ↗11“Sodium thiosulfate (STS) is currently used as a cyanide poisoning antagonist and a chemoprotectant against adverse effects of several chemotherapies such as Cisplatin.” NCT03582800 ↗ “Chronic treatment and prophylaxis of vessel and soft tissue calcification as well as of renal calculi could be a future indication for sodium thiosulfate (STS).” NCT02624479 ↗ “There are several case series that have shown the effectiveness of injecting a chemical compound called sodium thiosulfate (or "STS") into calcinosis lesions.” NCT06672822 ↗ “Sodium thiosulfate (STS) is a H2S-donor with known safety and efficacy profile in humans for other diseases, including calciphylaxis and cyanide poisoning.” NCT05277285 ↗ “Sodium thiosulfate (STS) has recently been used with success in the treatment of tumoral calcinosis.” PMID 31673978 ↗ Nov 2019 “Sodium thiosulfate solution (STS) has been used to neutralize iodine after Lugol's chromoendoscopy” PMID 34371004 ↗ Aug 2021 “Sodium thiosulfate (STS) (Na2S2O3) is primarily used to prevent and treat cyanide poisoning.” NCT04251832 ↗ “Transtympanic sodium thiosulphate (STS) 0.1M/0,5% hyaluronate” NCT07281508 ↗ “125mg/50ml sodium thiosulfate (STS) solution” NCT03639779 ↗ “H2S-donor sodium thiosulfate (STS)” PMID 34534493 ↗ Sep 2021 “Sodium Thiosulfate (STS)” NCT04132882 ↗ |
| Known as | Thiosulfuric Acid Disodium Salt | “Thiosulfuric Acid Disodium Salt” NCT00983398 ↗ |
| Action | Inhibit | “may block Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) entry into the host cells by interrupting Angiotensin-Converting Enzyme-2 (ACE2) and transmembrane...” NCT05277285 ↗ |
| Modality | Diagnostic / imaging agent | “Sodium thiosulfate-Methylene blue (DMB) staining solution was used as nerve staining agent.” NCT05232357 ↗ |
| Route | Intravenous | “Infused IV x 2 days” NCT00074165 ↗ |
| Target | ACE2 | “interrupting Angiotensin-Converting Enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2)” NCT05277285 ↗ |
| Target | TMPRSS2 | “interrupting Angiotensin-Converting Enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2)” NCT05277285 ↗ |