drugset / Trial / NCT00002461
Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma
RandomizedParallel-groupTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. Bone marrow or peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy to kill more cancer cells. PURPOSE: This phase II trial is studying giving high-dose chemotherapy followed by bone marrow or peripheral stem cell transplantation to see how well it works in treating patients with refractory Hodgkin's disease or non-Hodgkin's lymphoma.
Timeline
- Start
- 1988-04
- Primary completion
- 1991-07
- Completion
- 1991-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cisplatin | Other / unclassified | 200 mg/m2 | Intravenous |
| Subject | Cyclophosphamide | Other / unclassified | — | Intravenous |
| Subject | Etoposide | Small molecule | 2400 mg/m2 | Intravenous |
| Subject | Etoposide | Small molecule | 3000 mg/m2 | Intravenous |
| Subject | carmustine | Small molecule | 600 mg/m2 | Intravenous |
| Subject | carmustine | Small molecule | 1050 mg/m2 | Intravenous |
| Subject | filgrastim | Protein / enzyme biologic | — | Subcutaneous |
| Subject | sargramostim | Protein / enzyme biologic | — | Subcutaneous |