drugset / Trial / NCT00002552
Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma
Phase 2
Completed
40 enrolled
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI) · collab
Treatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining bone marrow transplantation with chemotherapy may allow doctors to give higher doses of chemotherapy and kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving a bone marrow transplant together with chemotherapy and to see how well it works in treating patients with refractory non-Hodgkin's lymphoma, Hodgkin's lymphoma, or multiple myeloma.
Timeline
- Start
- 1993-10
- Primary completion
- 2001-09
- Completion
- 2003-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclophosphamide | Other / unclassified | — | Intravenous |
| Subject | Etoposide | Small molecule | — | Intravenous |
| Subject | carmustine | Small molecule | — | Intravenous |
| Background | Cytarabine | Small molecule | — | Subcutaneous |
| Background | Hydrocortisone | Other / unclassified | — | — |
| Background | Leucovorin | Small molecule | — | — |
| Background | Methotrexate | Small molecule | — | — |
| Background | filgrastim | Protein / enzyme biologic | — | — |
| Background | perfosfamide | Small molecule | — | — |
| Background | sargramostim | Protein / enzyme biologic | — | Subcutaneous |