drugset / Trial / NCT00072280
Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma
Non-randomizedParallel-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Giving combination chemotherapy before surgery may shrink the tumor so that it can be removed. Giving combination chemotherapy after surgery may kill any remaining tumor cells. PURPOSE: This phase II trial is studying how well surgery and/or combination chemotherapy work in treating children with fibrosarcoma.
Timeline
- Start
- 2004-11
- Primary completion
- 2008-03
- Completion
- 2008-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclophosphamide | Other / unclassified | 25 mg/kg | Intravenous |
| Subject | Dactinomycin | Protein / enzyme biologic | 0.025 mg/kg | Intravenous |
| Subject | Dactinomycin | Protein / enzyme biologic | 0.045 mg/kg | Intravenous |
| Subject | Etoposide | Small molecule | 3.3 mg/kg | Intravenous |
| Subject | Ifosfamide | Small molecule | 60 mg/kg | Intravenous |
| Subject | Vincristine | Small molecule | 0.05 mg/kg | Intravenous |
| Background | filgrastim | Protein / enzyme biologic | — | Intravenous |
| Background | mercaptoethane sulfonate | Unknown | 60 % | Oral |