drugset / Trial / NCT00165139
Intensive Chemo-Radiotherapy With Peripheral Blood Progenitor Cell Rescue for Children With Advanced Neuroblastoma and Sarcomas
Phase 2
Completed
20 enrolled
Dana-Farber Cancer Institute
Boston Children's Hospital · collabChildren's Hospital of Philadelphia · collab
Non-randomizedSingle-groupOpen-labelTreatment
Summary
The main purpose of this study is to determine the short and long term side effects of a very intensive treatment, which includes combinations of chemotherapy drugs followed by radiation therapy and two transplants supported by peripheral blood progenitor cells (stem cells), for children with advanced stage neuroblastoma and sarcomas.
Timeline
- Start
- 1996-01
- Primary completion
- 2000-11
- Completion
- 2009-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carboplatin | Small molecule | — | Intravenous |
| Subject | Cisplatin | Other / unclassified | — | Intravenous |
| Subject | Cyclophosphamide | Other / unclassified | — | Intravenous |
| Subject | Doxorubicin | Other / unclassified | — | Intravenous |
| Subject | Etoposide | Small molecule | — | Intravenous |
| Subject | Ifosfamide | Small molecule | — | — |
| Subject | Melphalan | Small molecule | — | — |
| Subject | Vincristine | Small molecule | — | Intravenous |
| Background | 2-MERCAPTOETHANESULFONIC ACID | Small molecule | — | — |
| Background | Granulocyte colony-stimulating factor | Protein / enzyme biologic | — | Subcutaneous |