drugset / Trial / NCT00706277
Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function
RandomizedParallel-groupTriple-blindTreatment
Summary
The aim of the study is to investigate the effects of total intravenous anesthesia (TIVA; propofol, remifentanil) and balanced anesthesia (BAL; induction with propofol and fentanyl; maintenance of anesthesia with sevoflurane and nitrous oxide) on pulmonary function 30 minutes after emergence from the general anesthesia.
Timeline
- Start
- 2008-06
- Primary completion
- —
- Completion
- 2008-12
Publications
- Background Gunnarsson L, Lindberg P, Tokics L, Thorstensson O, Thorne A. Lung function after open versus laparoscopic cholecystectomy. Acta Anaesthesiol Scand. 1995 Apr;39(3):302-6. doi: 10.1111/j.1399-6576.1995.tb04066.x.
- Background Regli A, von Ungern-Sternberg BS, Reber A, Schneider MC. Impact of spinal anaesthesia on peri-operative lung volumes in obese and morbidly obese female patients. Anaesthesia. 2006 Mar;61(3):215-21. doi: 10.1111/j.1365-2044.2005.04441.x.
- Background Natalini G, Franceschetti ME, Pletti C, Recupero D, Lanza G, Bernardini A. Impact of laryngeal mask airway and tracheal tube on pulmonary function during the early postoperative period. Acta Anaesthesiol Scand. 2002 May;46(5):525-8. doi: 10.1034/j.1399-6576.2002.460509.x.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Fentanyl | Other / unclassified | 100 ug | — |
| Comparator | Nitrous Oxide | Other / unclassified | — | — |
| Comparator | Propofol | Small molecule | 2 mg | Intravenous |
| Comparator | Propofol | Small molecule | 6 mg/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.25 ug/kg | Intravenous |
| Comparator | Sevoflurane | Other / unclassified | — | — |
Indications
No indication recorded.