drugset / Trial / NCT00840684
Laromustine, Daunorubicin, and Cytarabine in Treating Patients With Acute Myeloid Leukemia
Non-randomizedOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy, such as laromustine, daunorubicin, and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of laromustine when given together with daunorubicin and cytarabine in treating patients with acute myeloid leukemia.
Timeline
- Start
- 2009-01
- Primary completion
- 2011-05
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | laromustine | Other / unclassified | — | Intravenous |
| Background | Busulfan | Small molecule | — | — |
| Background | Cytarabine | Small molecule | — | Intravenous |
| Background | Daunorubicin | Small molecule | — | Intravenous |
| Background | Melphalan | Small molecule | — | — |
| Background | Mitoxantrone | Small molecule | — | — |
| Background | amsacrine | Small molecule | — | — |