drugset / Trial / NCT01775475
Intravenous Chemotherapy or Oral Chemotherapy in Treating Patients With Previously Untreated Stage III-IV HIV-Associated Non-Hodgkin Lymphoma
Phase 2
Completed
7 enrolled
AIDS Malignancy Consortium
National Cancer Institute (NCI) · collabThe Emmes Company, LLC · collabUniversity of Arkansas · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This randomized phase II trial studies how well intravenous (IV) chemotherapy or oral chemotherapy works in treating patients with previously untreated stage III-IV human immunodeficiency virus (HIV)-associated non-Hodgkin lymphoma. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, prednisone, lomustine, etoposide, and procarbazine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells
Timeline
- Start
- 2016-09-15
- Primary completion
- 2021-04-01
- Completion
- 2021-07-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclophosphamide | Other / unclassified | — | Intravenous |
| Comparator | Doxorubicin | Other / unclassified | — | Intravenous |
| Subject | Etoposide | Small molecule | — | Oral |
| Subject | Lomustine | Small molecule | — | Oral |
| Comparator | Prednisone | Other / unclassified | — | Oral |
| Comparator | Vincristine | Small molecule | — | Intravenous |
| Subject | procarbazine | Small molecule | — | Oral |