drugset / Trial / NCT02299349

Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection

NCT02299349

Completed 70 enrolled TriHealth Inc.
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Despite a robust multimodal pain management regimen, patients undergoing total knee arthroplasty (TKA) continue to report low satisfaction with postoperative pain management. Patient satisfaction further declines with any adverse event such as a drug reaction to neuroleptic medications or a patient fall due to a femoral nerve block. A new method of pain management throughout the hospital experience is warranted to improve patient satisfaction and the possibility of related adverse events. The purpose of this study is to examine if there is a difference in post operative pain and morphine (MSO4) total consumption for hospitalized TKA patients without femoral nerve block receiving an intra-operative periarticular injection of bupivacaine liposome suspension versus a concentrated multi drug.

Timeline

Start
2013-08
Primary completion
2013-12
Completion
2014-03

Drugs

EvaluationDrugModalityDoseRoute
Subject Bupivacaine Other / unclassified Other
Comparator Epinephrine Other / unclassified 0.6 mg Other
Comparator Ketorolac Other / unclassified 30 mg Other
Comparator Morphine Other / unclassified 5 mg Other
Comparator Ropivacaine Other / unclassified 400 mg Other

Indications

No indication recorded.