Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery

Phase 4 Unknown 50 enrolled Korea University Anam Hospital

RandomizedParallel-groupDouble-blindSupportive care

Summary

During endoscopic sinus surgery (ESS), epinephrine local injection and controlled hypotension is essential in order to increase the visibility in the operative field and reduce the risk. This study is comparing of dexmedetomidine and remifentanil before epinephrine local injection for controlled hypotension during ESS.

Timeline

Start: 2015-08
Primary completion: 2015-11
Completion: 2016-09

Publications

Results Lee J, Kim Y, Park C, Jeon Y, Kim D, Joo J, Kang H. Comparison between dexmedetomidine and remifentanil for controlled hypotension and recovery in endoscopic sinus surgery. Ann Otol Rhinol Laryngol. 2013 Jul;122(7):421-6. doi: 10.1177/000348941312200702.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.4 ug/kg	Intravenous
Subject	Dexmedetomidine	Other / unclassified	0.8 ug/kg	Intravenous
Comparator	Remifentanil	Small molecule	0.2 ug/kg	Intravenous
Comparator	Remifentanil	Small molecule	0.4 ug/kg	Intravenous
Background	Epinephrine	Other / unclassified	—	Other
Background	Propofol	Small molecule	2 mg/kg	Intravenous
Background	Rocuronium	Other / unclassified	0.6 mg/kg	Intravenous

Indications

No indication recorded.